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Funding This study was partially supported by the National Natural Science Foundation of China (32070919 and 32270919), the Natural Science Foundation of Jiangsu Province (BK20201442), Jiangsu Specially-Appointed Professor, and Start-up funds for young scientists of Nantong University (03083051)

GLOBAL GLUTATHIONE MARKET SIZE, BY ONLINE PHARMACY, BY COUNTRY, 2018-2032 (USD MILLION) TABLE 176

As the rate-limiting enzyme of the SSP, PHGDH high expression is closely correlated with the malignancy of PDAC, and targeting PHGDH effectively inhibits the growth of pancreatic cancer cells under nutrient-deprived conditions (74, 76)