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Peptide Science 14 min read Five Peptides Every Endurance Athlete Should Understand From Mitochondrial Signaling to Connective-Tissue Remodelingand How AI Helps By Tony Medrano, LongevityPlan.AI Five Peptides Every Endurance Athlete Should UnderstandFrom Mitochondrial Signaling to Connective-Tissue Remodelingand How AI Helps By Tony Medrano | CEO & Co-Founder | LongevityPlan.AI | March 2026 Introduction: Why Peptides Are the New Frontier for Endurance Athletes In the spring of 2015, a small laboratory at the USC Leonard Davis School of Gerontology announced something that made exercise physiologists sit up straight: a sixteen-amino-acid molecule encoded not in our familiar nuclear DNA but in our mitochondrial genome could, when injected into obese mice, replicate many metabolic benefits of exercisesuppressing weight gain, reversing insulin resistance, and boosting endurance

Supplementary Figure 2 (A) The heatmap of the top 100 altered metabolites in R vs LC, and (B) , LC vs HC

There, it plays a key role in protecting and healing the gut lining

Thyssen et al