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Notably, supplementing NADPH and using a pharmacological inhibitor of aldose reductase an enzyme using NADPH oxidase for the formation of sorbitol in high-glucose conditions - successfully restored the sensitivity to LPS-induced NET formation in high glucose conditions, while reducing high glucose-induced cytosolic ROS production, neutrophil elastase secretion and spontaneous NET release (Joshi et al., 2020) (Table 4)

Low quality evidence, suggestion reflects expert opinion 125mg orally on day 1 and 80 mg on day 2 and 3 [15]

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ApoC-III inhibits hepatic uptake of TRL remnants uptake by displacing ApoE from the lipoprotein surface