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DNA methylation is a process in which DNMT catalyzes the covalent binding of SAM with a methyl to form 5mC

Oxidative stress plays a critical role in the pathophysiology of obesity by increasing the inflammatory response in adipose tissue and stimulating the differentiation of preadipocytes into mature adipocytes, thereby inhibiting fatty acid oxidation (FAO) and ultimately promoting adipogenesis (Kasprzak-Drozd et al., 2022)