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This is clinically relevant because obesity itself is associated with numerous health conditions that might influence treatment tolerance, including metabolic syndrome, cardiovascular disease, sleep apnea, and hepatic steatosis

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Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed

J Diabetes Complications