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Given the pivotal roles the pathophysiology and signaling pathways play in ischemic stroke, numerous therapeutic approaches have been explored in both experimental and clinical studies, and several of them have been demonstrated to be effective in treatment of ischemic stroke (Table 2)

In a model of Alzheimers disease, methysticin (6 mg/kg bodyweight) significantly reduced the secretion of TNF- and IL-17A and improved the symptoms of the disease [52]

In contrast, the levels of cytokines involved in the control of melanocyte proliferation and differentiation and the inhibition of melanogenesis, IL-17, IL-4 and IL-6, were significantly increased in the vitiligo group compared with the control group

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