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Packaging and Discretion Most retailers understand the preference for discreet packaging and ship nicotine pouches in plain boxes or envelopes without external branding

Smoking coronary heart disease , one of the leading causes of death in the U.S a heart attack , as smoking damages blood vessels blockages that reduce blood flow to the skin and legs stroke due to blood clots or burst blood vessels in the brain Carbon monoxide and nicotine make the heart work harder and faster

FUNDING This work was supported by the Startup funds of AEH and MAS

Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes