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The apparent discrepancy between WT and APP/PS1 animals is likely related to the involvement of constitutive oxidative stress associated to amyloid generation in the brain of transgenic animals (Aso et al., 2006)

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While levodopa has all of these side effects, other PD medications might cause sleep difficulties and cognitive issues such disorientation and psychosis, MAO-B inhibitors, COMT inhibitors, and other similar drugs anticholinergic medications (Yuan et al., 2010)