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Lastly, syndromes of neurodegeneration with brain iron accumulation (NBIA), such as pantothenate kinase-associated neurodegeneration (PKAN), exemplify the devastating clinical effects of ferroptosis driven by excessive iron deposition

For example, the spacer can be selected from the group consisting of -C1-C10 alkylene- , -C1-C10 heteroalkylene-, -C3-C8 carbocyclo-, -O-(Ci Cs alkyl)-, -arylene-, -C1-C10 alkylene-arylene-, -arylene-C-i-C-io alkylene-, -C1-C10 alkylene-(C3-Cs carbocyclo)-, -(C3- Cs carbocyclo)-Ci-Cio alkylene-, -C3-C8 heterocyclo-, -C1-C10 alkylene-(C3- Cs heterocyclo)-, -(C3-C8 heterocyclo)-Ci-Cio alkylene-, -C1-C10 alkylene-C(=O)-, -C1- C10 heteroalkylene-C(=O)-, -C3-C8 carbocyclo-C(=O)-, -O-(Ci-Cs alkyl)-C(=O)-, -arylene- C(=O)-, -C1-C10 alkylene-arylene-C(=O)-, -arylene-Ci-Cw alkylene-C(=O)-, -C1- C10 alkylene-(C3-C8carbocyclo)-C(=O)-, -(C3-C8 carbocyclo)-Ci-Cio alkylene-C(=O)-, - C3-C8 heterocyclo-C(=O)-, -C1-C10 alkylene-(C3-C8heterocyclo)-C(=O)-, -(C3- Cs heterocyclo)-Ci-Cio alkylene-C(=O)-, -C1-C10 alkylene-NH-, -C1-C10 heteroalkylene- NH-, -C3-C8 carbocyclo-NH-, -O-(Ci-Cs alkyl)-NH-, -arylene-NH-, -C1-C10 alkylene- arylene-NH-, -arylene-Ci-Cw alkylene-NH-, -C1-C10 alkylene-(C3-Cs carbocyclo)-NH-, - (C3-C8 carbocyclo)-Ci-Cio alkylene-NH-, -Cs-Csheterocyclo-NH-, -C1-C10 alkylene-(C3- Cs heterocyclo)-NH-, -(C3-C8 heterocyclo)-Ci-Cio alkylene-NH-, -Ci-Cwalkylene-S-, -C1- C10 heteroalkylene-S -, -Cs-Cscarbocyclo-S -, -O-(Ci-Cs alkyl)-)-S -, -arylene-S-, -C1-C10 alkylene-arylene-S-, -arylene-Ci-Cw alkylene-S-, -Ci-Cio alkylene-(C3-Cs carbocyclo)-S- , -(C3-C8 carbocyclo)-Ci-Cio alkylene-S-, -C3-C8 heterocyclo-S-, -C1-C10 alkylene-(C3- Cs heterocyclo)-S-, -(C3-C8 heterocyclo)-Ci-Cio alkylene-S-, -C1-C10 alkylene-O-C(=O)-, -C3-C8 carbocyclo-O-C(=O)-, -O-(Ci-Cs alkyl)-O-C(=O)-, -arylene-O-C(=O)-, -C1- C10 alkylene-arylene-O-C(=O)-, -arylene-Ci-Cw alkylene-O-C(=O)-, -C1-C10 alkylene- (C3-C8carbocyclo)-O-C(=O)-,-(C3-C8 carbocyclo)-Ci-Cio alkylene-O-C(=O)-, -C3- Cs heterocyclo-O-C(=O)-, -C1-C10 alkylene-(C3-C8heterocyclo)-O-C(=O)-, and -(C3- Cs heterocyclo)-Ci-Cio alkylene-O-C(=O)-

!conteudo= !item= !caixaGeral= Desde 1995 oferecendo sade e boa forma

Moreover, the availability of pharmacological agents capable of selectively regulating lipid metabolism with high precision remains limited due to the highly interconnected nature of lipid metabolic processes and their complex regulatory networks [113]