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Oxidative stress plays an important role in the pathophysiological process of depression through the role of free radicals, non-free radical molecules, reactive oxygen species, and reactive nitrogen

Some people have emailed to tell me that prolotherapy cured them when nothing else did, and other people have said it made them worse and they wished they hadn't tried it

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10.1007/s12035-025-04948-9 Summary Keywords cannabis, epigenesis, genetic, hypothalamic-pituitary-adrenal axis, major depressive disorder, neuroinflammation Citation Pilatti F, Philippsen M, Bertollo AG, Webler CP, Bordignon AK and Igncio ZM (2026) Interplay between the HPA axis and inflammation as mechanisms therapeutic targets of Cannabis sativa in depression