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Acknowledgments Thanks for the reviewers for their helpful comments on this paper, and thank American Journal Experts (AJE) for English language editing

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Published by Cambridge University Press on behalf of The Nutrition Society From experiments in mice in the 1970s, we learned that not only was selenium (Se) supplementation able to affect the immune response (Reference Spallholz, Martin and Gerlach1) but data from the 1990s also showed that Se status influenced the ability of mice to deal with viral infection (Reference Beck, Handy and Levander2)