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The upregulation of GPX2 leads to the clearance of H 2 O 2 , the inhibition of apoptosis, and the weakening of oxidative stress

NR supplementation using a single oral 1,000 mg dose showed the ability to raise 2.7-fold NAD+ in human blood (Trammell et al., 2016)

N6F11-induced ferroptosis promotes HMGB1 release, activates CD8 + T cell-mediated anti-tumor immunity, and synergizes with PD-L1 inhibitors to enhance therapeutic efficacy against KRAS/TP53 mutant pancreatic cancer, thus providing a new strategy for tumor immunotherapy (Li et al., 2023a)