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The evidence on weight is strongest for post-menopausal breast cancer and cancer of the endometrium (lining of the womb), gall bladder and kidney

Research published in Nature Medicine demonstrated that MOTS-c improved insulin sensitivity even in diet-induced obesity models, while studies on 5-Amino-1MQ showed NAD+ restoration and reduced adiposity in insulin-resistant rodents

NICE guidance emphasises investigating the underlying cause of B12 deficiency rather than simply treating with supplements