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Goldstein, B

Six of the saline group were not sleep deprived

Abrupt cessation wont cause withdrawal symptoms or rebound effects, but metabolic markers will gradually return to baseline over 24 weeks as AMPK activity normalizes and NNMT inhibition wears off

Figure 2 3.3 Expression and localisation of core clock component proteins in the lens at different times of the day To determine if time of day differences existed in clock protein expression, we investigated whether the expression of BMAL1, CLOCK and CRY2 oscillated over a 24-hour period