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Regarding preclinical studies, there are several unexplored research opportunities for experimental animal studies using, for example, (1) chronic short sleep duration or chronic sleep fragmentation models, (2) circadian misalignment/jetlag models including a urolithin A intervention arm, and (3) germ-free mice or fecal matter transplant to investigate whether the effects of urolithin A are dependent on the microbiota

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M.JeavonsS.TaniousM.KohlmannK.et al (2014)

High-fat diet modulates hepatic amyloid beta and cerebrosterol metabolism in the triple transgenic mouse model of Alzheimers disease