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In macrophages infected with Leishmania donovani , activation of PINK1/Parkin-mediated mitophagy reduces mtROS accumulation and prevents uncontrolled inflammasome activation ( 5.5 Parasite-induced mitochondrial signaling and immune evasion Mitochondria orchestrate several innate immune pathways critical for parasite control, including NLRP3 inflammasome activation and type I interferon responses

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A molecular mimicry hypothesis proposes that HLA-B27 itself becomes autoantigenic due to its sequence homology with certain bacterial proteins

The TCs have been associated with various biological properties, such as antiviral especially as inhibitors of the replication of Herpes, antibiotic, antimalarial, antileukemic and immunotoxic [59,186]