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"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity." Nature

(7) Kong YX, Li ZS, Liu YB, Pan B, Fu X, Xiao R, Yan L

Unlike traditional weight loss medications, Tirzepatide is a dual GIP and GLP-1 receptor agonist , meaning it targets two powerful hormonal pathways that control appetite, digestion, and blood sugar