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While it's broadly deemed safe, some users may experience gastrointestinal upsets, occasional headaches, or skin irritations

Vitamin B12 overdose & toxicity

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found no CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitts lymphoma cells was observed (Wang et al., 2019)