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Cautions: Do not give B12 injections to someone with a known hypersensitivity to cyanocobalamin, hydroxocobalamin, or cobalt

Although AOD 9604 does not affect blood sugar, people actively managing diabetes with medication should monitor more carefully when adding any new compound to their regimen

Advantages of oral form over IM injection: Less nursing time on injections Less complexity of care Less discomfort/pain Less bleeding in patients who take anticoagulants Less costly according to some analyses Disadvantages of oral form over IM injection:: Greater risk of non-compliance In 1991, a survey done on Minneapolis internists led one commentary to conclude that oral vitamin B 12 replacement for pernicious anemia was one of medicines best kept secret. 18 In 1996, when the survey was repeated again in the same area, awareness and use of oral vitamin B 12 for pernicious anemia had increased substantially (019%), but the majority of doctors still remain unaware of this treatment option (61%)

IL-6 stimulation of insulin-like growth factor binding protein (IGFBP)-1 production