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George Clooney: Well, it's dumb to do because you're coming out and saying, "Well, let's try to-- get an audience to take this ride with you back to 1954." The play brings to life the humming CBS newsroom of the 1950sall typewriters and smoldering cigarettes

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Regarding this association, possible biological mechanisms elucidating the impact of smoking on anxiety include an array of processes, including the dopaminergic system, gamma-aminobutyric acid, hypothalamic-pituitary-adrenal axis, serotonin, and monoamine oxidase 26-28

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