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The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function

Following cartilage injuries, there is often a progression to osteoarthritis, which imposes a significant health burden on individuals and society

For example, using the chronic unpredictable mild stress (CUMS) model, studies have demonstrated that specific Chinese medicines significantly improve depressive-like behaviors in animals

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