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Description

This project allows the interrogation of mechanisms in both murine models and human tissue

Thus, we tested here whether increased VEGFA expression specifically in the RPE (and not in the retina or circulation) is sufficient to induce RPE barrier breakdown and neovascular AMDlike pathologies, by generating mice that overexpress VEGFA only in the RPE postnatally (Vmd2Cre +/WT /ROSASTOP fl/fl VEGFA 164 mice)