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found that SIRT1 improved the resilience of granulosa cells to apoptosis (Han et al

The residues of the key 6 YGS 8 motif within the GCT fold are located in loop 1, while the unique dimerization loop 2 is flipped away from the enzymes core domain (Nguyen et al., 2020)

This chelation property allows theaflavins to bind to free iron, thereby reducing iron's availability to participate in harmful reactions such as the Fenton reaction, which can lead to oxidative stress and cellular damage [14]

Saline was used as the vehicle for all compounds, except Phenylbutazone, which required corn oil due to poor aqueous solubility