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Results vary by patient profile and dosage

Now, as for the reversibility of nerve damage: In terms of neurological recovery from B12 deficiency, studies conducted on rats so far indicate that methyl B12 may promote the regeneration of nerves: Schwann cells (SCs) are constituents of the peripheral nervous system

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The main rationale for cycling rather than continuous use involves conservative safety practices given limited long-term human data, cost management, and theoretical concerns about receptor desensitization with extended exposure