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Hypertensive patients have been observed to produce high levels of hydrogen peroxide, superoxide anion, and NO in leukocytes [290,291,292], exhibit elevated lipid peroxidation in erythrocytes, and display elevated concentrations of 8-isoprostanes in plasma [293]

Philos Trans R Soc Lond Ser B Biol Sci 369:20130226 Gabara B, Kuniak E, Skodowska M, Surwka E, Miszalski Z (2012) Ultrastructural and metabolic modifications at the plantpathogen interface in Mesembryanthemum crystallinum leaves infected by Botrytis cinerea

Moreover, CARS2 heterozygous knockout mice, when exposed to elastase or cigarette smoke extract to induce COPD, manifested more severe disease phenotypes than did wild-type mice, thereby underscoring the protective role of supersulfides in COPD (16)

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