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Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells

Interestingly, renal excretion studies showed that the enhanced estrogen metabolism observed in both RA and SLE patients resulted in elevation of pro-inflammatory metabolites derived from estrone or estradiol such as 16-OHE 1 , which exert mitogenic effects and may induce proliferation of synovial fibroblast [68, 13]

Genomic approaches to the deconvolution of microenvironmental cellular subtypes are increasingly utilised in oncology research