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They are classified as "essential" or "non-essential", with essential amino acids meaning they cannot be manufactured by the body and must be supplied in the diet to maintain good all-round health

Among the remaining subjects, we further excluded those who received a diagnosis of bipolar disorder during the follow-up assessment (n = 9), those with missing metabolite data due to the lack of blood samples (n = 158) and those who did not complete the Inventory for Depressive Symptoms questionnaire (n = 33)