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Notably, the acetylation-defective P53 mutant (P53 3KR) can indirectly inhibit the uptake of cysteine, decrease GSH production, and induce lipid ROS accumulation, leading to ferroptosis [67, 74]

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Biodistribution and therapeutic effects in subcutaneous osteosarcoma mouse model The therapeutic properties of the nanoparticles were further studied inside an 143B tumor-bearing immunodeficient nude mouse model (Fig