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Moore MJ, Qu S, Tan C, Cai Y, Mogi Y, Jamin Keith D, et al

Combination approaches, blending prooxidants for cancer with antioxidants for protection, are gaining traction

The choice of method depends on the required sensitivity, specificity, and the nature of the sample being analyzed

Importantly, either genetic silencing of NCOA4 or treatment with the iron chelator deferoxamine (DFO) significantly attenuated these pathological changes, resulting in over 60% improvement in neuronal survival (Plascencia-Villa and Perry, 2021)