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A few commenters proposed replacing the quartile-based approach with a system based on fixed, evidence-based benchmarks that reflect meaningful differences in performance, rather than rankings relative to peers

These observations are consistent with the hypothesis that enhancement of glycine-dependent signaling may mitigate aspects of NMDA receptor hypofunction, a mechanism widely implicated in the pathophysiology of schizophrenia (Zhang et al

Using a multi-omics approach, we examined the outcomes of independently knocking down 438 antioxidative stress genes by analysing the Broad Institutes Project Achilles dataset (genome-wide shRNA knockdown in 201 cancer cell lines 16 ) (see Methods)

The proteins encoded by these genes, including Pax6, Pitx3, c-Maf and Foxe3, are transcription factors