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Similarly, when investigating DNA methylation and gene expression in human sural nerve biopsies, Guo et al

van Hoorn, P

This is further validated in human PBMCs that AGEs-exposure promoted Th2 differentiation and pro-inflammatory responses involving activation of the RAGE and TLR4 signaling axes

Notably, the extent of metabolic decline is inversely correlated with Beck Depression Inventory-II (BDI-II) scores, suggesting an association between impaired brain energetics and depressive symptom severity (119)