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There is some evidence that L-carnitine may help preserve lean muscle mass during calorie restriction, though the data is mixed and the effect sizes are small

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Tendon and Ligament Repair Moderate to Strong Evidence Evidence Rating: Moderate-Strong (Several animal studies, some independent replication) Research support for musculoskeletal healing is substantial: Achilles tendon injuries Ligament damage (MCL, ACL) Rotator cuff healing General tendinopathy Surgical repair enhancement The FAK-paxillin mechanism and VEGF upregulation provide clear biological rationale for these effects

Treatment Duration and Cycling Treatment duration and cycling follows patterns without evidentiary basis: active phase of 6-12 weeks continuous use followed by 4-8 week breaks