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The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

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Collectively, these data from yeast show that methionine while strongly drive anabolic processes, all these are closely tied to NADPH synthesis and utilization

In general, gene mutations with large biological effects (i.e., optic neuropathy) are rare whereas gene variants associated with smaller effects are common (12) (see below)