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Hence, AuNPs have been specifically designed to have anti-angiogenic effects in diseases where angiogenesis (the growth and extension of blood vessels from pre-existing blood vessels) spins out of control like cancer, rheumatoid arthritis, macular degeneration and obesity [5, 25, 113, 117]

Kushner T, Serper M, Kaplan DE

In conclusion, the accumulation of specific uremic toxins in CKDsuch as indoxyl sulfate, phosphate, vanadate, and acroleinpromotes eryptosis through distinct but convergent mechanisms involving Ca 2+ dysregulation, oxidative stress, energy depletion, and kinase activation