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With carbidopa administration the resulting B6 depletion may lead to collapse of central and peripheral B6-dependent enzymes including AADC which metabolizes L-dopa to dopamine

I feel like this study missed the forest for the trees

10.1016/j.jdiacomp.2008.04.001 J Diabetes Complications

With K d values of 10 -10 mol/L and 10 -9 mol/L, respectively, FR- and FR- demonstrate remarkably comparable affinities for FA despite the difference in their carboxy-terminal sequences