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metformin in children with NAFLD, showed that both improved hepatocellular ballooning and the NAFLD activity score (NAS), but neither vitamin E nor metformin decreased alanine aminotransferase (ALT) values or hepatic steatosis, inflammation, or fibrosis in NASH

S., Graciliano, N

A typical example is to develop an MnO 2 -based nanocarrier for chemotherapeutics delivery, which could degrade and release drugs in response to overexpressed GSH (Lin et al., 2018)

The reason for occurring this phenomenon (reduction of CySGly- but not of GS-bound Mercury(II)) in solution and in the biological environment of cells is reasonably a consequence of the low reducing electrochemical potential of CySGly (at 0.282 V the most reducing one of the whole soluble physiological thiolome)