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The signaling-epigenetic-metabolic axis: a self-reinforcing oncogenic circuit The limitations of single-target therapy and the theoretical basis of combination treatment strategies all originate from a precise, dynamic, and self-reinforcing triangular regulatory network in tumor cells - this network covers DNA methylation, metabolic reprogramming, and oncogenic signaling pathways

Neuroendocrine Signaling Experimental studies continue to examine the role of melanocortin signaling in central nervous system communication and neuroendocrine regulation

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These findings suggested that lipoprotein distributions of apoC3 and apoA5 were closely associated with the TG contents in TRL