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The importance of considering circadian rhythm and metabolic regulation in drug design is emphasized

Therefore, further elucidating the pathogenesis of RA and identifying new therapeutic targets will help develop more personalized, effective, and safe treatment approaches, thereby improving the quality of life of RA patients and reducing the socioeconomic burden of the disease

Differences were tested for significance by one-way or two-way ANOVA, followed by Bonferronis post hoc test, p 100 M (Fig

A significant increase in hepatic STAT3 phosphorylation and acetylation and binding of FXR to Stat3 promoter, as well as decreased apoptosis markers by flow cytometry (FAS, caspase 8 and caspase 3), were present in FXR agonist/DDC mice compared to DDC mice