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Yan MM, Zhao H, Li ZR, Chow JW, Zhang Q, Qi YP, Wu SS, et al

Vitamin C, or ascorbic acid, is essential for a variety of biological processes

[22] Diphenhydramine acts as a reversible, competitive antagonist-and more precisely, an inverse agonist-at the histamine H receptor, thereby stabilizing the inactive receptor conformation and preventing histamine-mediated vasodilation, increased capillary permeability, and sensory nerve activation