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You will see it stated confidently in a lot of places that the body adapts after 4 to 6 weeks, tolerance builds, and the effect fades, so you have to cycle. It sounds authoritative

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Discussion Selenium-induced antioxidant enzyme activation (H1) The first hypothesis tested in this study was that increasing concentrations of NaSeO in corn hydrolysate would stimulate the activity of antioxidant enzymes (GPx, GR, and GST) in Saccharomyces cerevisiae Thermosacc strain, with higher enzyme activity expected under aerobic conditions due to enhanced energy availability and oxygen-dependent redox regulation

Zhang X, Artola-Boran M, Fallegger A, Arnold IC, Weber A, Reuter S, Taube C, Muller A (2020) IRF4 expression is required for the immunoregulatory activity of conventional type 2 dendritic cells in settings of chronic bacterial infection and cancer