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Liao X, Liu Y, Fu X, Li Y (2020) Postmortem studies of neuroinflammation in autism spectrum disorder: a systematic review

Nrf2 also promotes purine base synthesis through the indirect regulation of phosphoribosyl-pyrophosphate amidotransferase (catalyzes the rate-limiting step in purine biosynthesis), and methylenetetrahydrofolate dehydrogenase 2 (a nuclear-encoded mitochondrial enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities) [50]