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Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy

In a pool of two ZEPBOUND clinical trials for weight reduction (Studies 1 and 2), 0.2% of ZEPBOUND-treated patients had acute pancreatitis confirmed by adjudication (0.14 patients per 100 years of exposure) versus 0.2% of placebo-treated patients (0.15 patients per 100 years of exposure)

Analogously, LNCaP cells were cultured in CDSS-containing medium for 8 weeks to generate castration-resistant LNCaP-CR cells, followed by Enza exposure (50 M, 2 weeks) to derive LNCaP-C/Enza-R cells which were then used, together with LNCaP-AD cells in ABT-199 sensitivity studies (supplementary Fig