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The constructed PD-L1-targeted metabolism and immunomodulator (PMIR) is used to regulate metabolism in the TME to improve immunotherapy

A related study found that LND and BPTES were able to induce glycolysis and inhibit glutamine metabolism, which was accompanied by significant mitochondrial damage, ultimately blocking energy supply and posing a threat to tumour survival, to efficiently kill tumours

Increased ROS level above the cellular tolerability threshold results in apoptotic or necrotic cell death

Disclosures: Katelynn Madill-Thomsen: Nothing to Disclose, Jeff Reeve: Nothing to Disclose, Sunil Kurian: Nothing to Disclose, Philip Halloran: Nothing to Disclose, Josh Levitsky: Nothing to Disclose 1311 ADVANCEMENTS IN LIVER TRANSPLANT OUTOMES FROM 1997 TO 2023 Fawaz Al Ammary 1 Abhinav Humar 2 Simeon Adeyemo 1 Kate Kriby 1 Ahmet Gurakar 3 , 1 University of California Irvine, 2 University of Pittsburgh Medical Center, 3 Johns Hopkins University Background: Improvment in liver transplant techniques and immunosuppression impact the lifespan of liver transplantation