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Statements Author contributions ZW: Data curation, Formal analysis, Investigation, Methodology, Writing original draft

As the bioavailability of cysteine is the rate limiting factor for synthesis of GSH [3134], the lower cysteine levels detected in serum of children with autistic disorder could be an important factor leading to the lower levels of GSH observed in many children with this condition [4648, 50, 81, 82]

Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria