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Analytische methode-ontwikkeling en validatie (HPLC, LC-MS, peptide-mapping) waarbij de langzame isomerisatie rond X-Pro-bindingen piekverbreding of pieksplitsing kan geven een veeleisende testcase voor kolomkeuze, kolomtemperatuur en gradintinstellingen

2316-C GPNMB CONTRIBUTES TO NASH PROGRESSION WITH M2 POLARIZATION OF HEPATIC MACROPHAGES AND ACTIVATION OF HEPATIC STELLATE CELLS Kenji Fukumoto 1 , Hayato Hikita 1 , Shusuke Kumazaki 1 , Seiya Kato 1 , Yoichi Sasaki 1 , Kazuhiro Murai 1 , Takahiro Kodama 2 , Tomohide Tatsumi 1 and Tetsuo Takehara 2 , (1)Osaka University, Graduate School of Medicine, (2)Osaka University Graduate School of Medicine Background: Recently, with the advent of single cell RNA analysis, NASH-associated macrophages (NAMs) characterized by high expression of TREM2 and GPNMB have attracted much attention

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Reveals interesting differences in the ability of STIM1 and STIM2 to mediate Ca 2+ entry in response to different PLC-coupled receptors and Ca 2+ oscillations that lead to the activation of gene expression