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Description

Optimizing these interactions requires balancing affinity, valency, and trafficking kinetics

Too much dopamine leads to more movement such as tics and involuntary movement

FEBS Open Bio 5 , 419428 (2015)

Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable